Genetic obese diabetic mice, including leptin and leptin receptor knockouts (ob/ob and db/db, resp.), are commonly used T2D models for developing new treatments for this disease. For the study of Type 2 diabetes (T2D) there are a variety of inbred mouse strains that serve as popular models.
These alarming statistics underscore the need for research aimed at discovering novel therapeutic strategies for the prevention or treatment of this disease. While the availability of novel drugs, techniques, and surgical intervention has improved the survival rate of individuals with diabetes, the prevalence of diabetes still rises in Americans, and the number of people with diabetes is projected to double by 2025. Almost the same numbers have prediabetes. It is estimated that 23.6 million or 8% of the American population suffers from diabetes. The combination of HFD and three 40 mg/kg STZ injections induced a model with metabolic characteristics of T2D, including peripheral insulin resistance and reduced β-cell mass. Islet mass was not affected by diet but was reduced by 50% in mice that received 3 STZ injections. Insulin sensitivity in HFD mice was lower than that of LFD mice, regardless of STZ treatment. Glucose tolerance was impaired in mice that consumed HFD and received 2, 3, or 4 injections of STZ. After 4 weeks, serum insulin levels were reduced in HFD mice administered at least 2 STZ injections as compared with HFC. 40 mg/kg BW streptozotocin (STZ) injection, (3), (4), (5), (6) LFD with 2, 3, 4, or 5 STZ injections on consecutive days, respectively, (7) high-fat diet (HFD), (8) HFD with 1 STZ injection, (9), (10), (11), (12) HFD with 2, 3, 4, or 5 STZ injections on consecutive days, respectively. Ninety-six 6-month-old C57BL/6N males were assigned to 1 of 12 groups including (1) low-fat diet (LFD low-fat control LFC), (2) LFD with 1 i.p. The objective of this study was to generate a nongenetic mouse model of T2D. Continued abuse of our services will cause your IP address to be blocked indefinitely.Insulin resistance and loss of β-cell mass cause Type 2 diabetes (T2D). Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior.
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